Transbuccal administration involves placing medication between which structures?

Transbuccal administration involves placing medication between which structures?

• A. Tongue and palate
• B. Cheek and gums
• C. Teeth and lips
• D. Cheek and tongue

Answer: (B)

Transbuccal administration uses the buccal mucosa, the thin, moist lining on the inside of the cheek. Placing medication between the cheek and the gums keeps it in direct contact with this mucosa, which is highly vascular and allows the drug to be absorbed quickly into the bloodstream while largely bypassing the digestive system. The other sites correspond to different oral surfaces (tongue-palate area, labial mucosa near the lips, or between cheek and tongue) and are not the buccal route used for systemic absorption.

Transbuccal administration uses the buccal mucosa, the thin, moist lining on the inside of the cheek. Placing medication between the cheek and the gums keeps it in direct contact with this mucosa, which is highly vascular and allows the drug to be absorbed quickly into the bloodstream while largely bypassing the digestive system. The other sites correspond to different oral surfaces (tongue-palate area, labial mucosa near the lips, or between cheek and tongue) and are not the buccal route used for systemic absorption.